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demonstrated that hypoxia induces YAP activation, leading to interaction with HIF-1 to form a YAP/HIF-1 complex that maintains the protein stability of HIF-1 and activates GLUT1 transcription, thereby directly accelerating glycolysis and the progression of PTC [102]

Kreider, R.B., Jung, Y.P

Participants were randomized to placebo or one of several retatrutide dose groups: 1mg, 4mg, 8mg, or 12mg, administered weekly by subcutaneous injection